Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

Described are compounds and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II:where:one of A or E is nitrogen, with remaining atoms carbon;X=O, S, NH or NR7, such that R7=lower...

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Bibliographische Detailangaben
Hauptverfasser:	MEYER ROBERT FREDERICK, FRY DAVID, KRAKER ALAN, DENNY WILLIAM ALEXANDER, THOMPSON ANDREW MARK, REWCASTLE GORDON WILLIAM, BRIDGES ALEXANDER JAMES
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described are compounds and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II:where:one of A or E is nitrogen, with remaining atoms carbon;X=O, S, NH or NR7, such that R7=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms). Other terms are described in the specification.