Chemical synthesis using solvent microdroplets

The present invention relates to microdroplets of a solution comprising a solvent having a boiling point of 150° C. or above, a surface tension of 30 dynes/cm or above, and a viscosity of 0.015 g/(cm)(sec). Such microdroplets are useful for the synthesis of chemical species, particularly biopolymers...

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Bibliographische Detailangaben
1. Verfasser:	BLANCHARD ALAN P
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY CORRECTION OF TYPOGRAPHICAL ERRORS DERIVATIVES THEREOF i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES LINING MACHINES MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES METALLURGY NANOTECHNOLOGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PRINTING SELECTIVE PRINTING MECHANISMS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES STAMPS SUGARS THEIR RELEVANT APPARATUS TRANSPORTING TYPEWRITERS
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Beschreibung
Zusammenfassung:	The present invention relates to microdroplets of a solution comprising a solvent having a boiling point of 150° C. or above, a surface tension of 30 dynes/cm or above, and a viscosity of 0.015 g/(cm)(sec). Such microdroplets are useful for the synthesis of chemical species, particularly biopolymers such as oligonucleotides and peptides, as well as arrays of chemical species. Preferably, the solvent has the formula (I):whereinA=O or S;X=O, S or N (C1-C4 alkyl)Y=O, S, N(C1-C4 alkyl) or CH2; andR=C1-C20 straight or branched chain alkyl.