2-alkylidene hydroxycoumaranone derivatives

2-alkylidene hydroxycoumaranone derivatives

New compounds of formula Iwherein:R and R1 are independently selected from hydrogen, (C1-C6)alkyl, styryl and (C3-C6)cycloalkyl or, taken together with the carbon to which they are linked, form a (C3-C6)cycloalkyl group;A is selected from the following groups:-CH2C=CCH2-,or -(CH2)q-NH-(CH2)q-,wherei...

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Bibliographische Detailangaben
Hauptverfasser: WOELLE SABINE, FRIEBE WALTER-GUNAR, KRELL HANS-WILLI, KOENIG BERNHARD
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:New compounds of formula Iwherein:R and R1 are independently selected from hydrogen, (C1-C6)alkyl, styryl and (C3-C6)cycloalkyl or, taken together with the carbon to which they are linked, form a (C3-C6)cycloalkyl group;A is selected from the following groups:-CH2C=CCH2-,or -(CH2)q-NH-(CH2)q-,wherein q is an integer from 2 to 3B is selected fromT is selected from -CH2-C=CH, -C=CH, -(CH2)p-R3, -CH=CH-R3, -CH2-NHCO-R3, -(CH2)p-O-R3, -CH(NH2)-CH2R3, in which p is 0 or an integer from 1 to 4,R3 is a carbocyclic or heterocyclic ring as medicaments having antitumor and/or antimetastatic activities.