Stabilized carbapenem antibiotic compositions and method of making

The present invention relates to a novel stabilized form of carbapenem antibiotics of formula II:compositions and methods thereof wherein the antibiotics and compositions are stabilized degradation and dimer formation. The compounds can be used in the treatment of infectious diseases, including gram positive and negative, aerobic and anaerobic bacteria. The compounds provide good stability against beta-lactamases, and a favorable duration of action.The compounds of this invention are represented structural formula I:or a pharmaceutically acceptable or hydrate thereof.