Heterocyclic cis cyclopropane derivatives as melatonergic agents

Heterocyclic cis cyclopropane derivatives as melatonergic agents

There is provided a novel series of cis cyclopropane compounds of Formula Iwherein R1, R2, R3, R4, X, Y, Z and m are as defined herein which bind to the human melatonin receptor and therefore are useful as melatonergic agents.

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Bibliographische Detailangaben
Hauptverfasser: CHEN JIE, TAKAKI KATHERINE S, DEXTRAZE PIERRE, DODIER MARCO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:There is provided a novel series of cis cyclopropane compounds of Formula Iwherein R1, R2, R3, R4, X, Y, Z and m are as defined herein which bind to the human melatonin receptor and therefore are useful as melatonergic agents.