Analog current mode assisted differential to single-ended read-out channel operable with an active pixel sensor

The present invention provides an active pixel sensor read-out channel that includes an active pixel. The active pixel drives an active pixel output to a signal voltage having an amplitude proportional to an intensity of light received by the active pixel. The active pixel drives the active pixel output to a reference voltage when the active pixel is not exposed to light. The active pixel output is connected to a sample and hold circuit. The sample and hold circuit samples and stores the signal voltage and samples and stores the reference voltage. A buffer amplifier generates a difference voltage between the sampled and stored signal voltage and the sampled and stored reference voltage.