Intermediates for the synthesis of camptothecin derivatives

Intermediates for the synthesis of camptothecin derivatives

Intermediates for the synthesis of camptothecin of the formula IIwherein:R1 is -(CH2)2NR1R2, where R1 is an amino protecting group and R2 is C2-C5 alkyl, hydroxyethyl or acetoxyethyl group, and of the formula IIIwherein:n is 1 or 2;R3 is hydrogen or -OR4, where R4 is hydrogen, -COR5, -CONHR6 or CH2O...

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Hauptverfasser: CHA KYEONG HOI, KIM MYOUNG GOO, KIM JOON KYUM, LEE KWANG KYUN, OK KWANG DAE, HAH JEONG MI, LEE HEE SOON, KIM JONG MIN, JEW SANG SUP, KIM HEE JIN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Intermediates for the synthesis of camptothecin of the formula IIwherein:R1 is -(CH2)2NR1R2, where R1 is an amino protecting group and R2 is C2-C5 alkyl, hydroxyethyl or acetoxyethyl group, and of the formula IIIwherein:n is 1 or 2;R3 is hydrogen or -OR4, where R4 is hydrogen, -COR5, -CONHR6 or CH2OR7, where R5 is methyl or -CH2OCH3, R6 is isopropyl, phenyl or -CH2CH2Cl, and R7 is methyl, ethyl or -CH2CH2OCH3; with the proviso that when n is 2, R3 is not hydrogen.