Spirodiamino acid scaffold for combinatorial synthesis

Azaspirononanes of formula I and their synthesisare disclosed. The compounds are useful as templates for constructing synthetic receptors and as intermediates in the synthesis of enzyme inhibitors. They are prepared by an intramolecular ylide cycloaddition of a 6-hydrazone of 2,10-undecadienoic acid...

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Hauptverfasser: BARDEN MICHAEL C, DOLLE, III ROLAND ELLWOOD
Format: Patent
Sprache:eng
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Zusammenfassung:Azaspirononanes of formula I and their synthesisare disclosed. The compounds are useful as templates for constructing synthetic receptors and as intermediates in the synthesis of enzyme inhibitors. They are prepared by an intramolecular ylide cycloaddition of a 6-hydrazone of 2,10-undecadienoic acid ester.