Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula(T)xA-B-D-E-Gwherein A and B are aryl or heteroaryl rings; each T is a substitu...
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| creator | BENZ GUENTER HANS HEINZ HERBERT SCHNEIDER STEPHAN COMBS KERRY JEANNE WOOD JILL ELIZABETH WILHELM SCOTT M VANZANDT MICHAEL CHRISTOPHER WOLANIN DONALD JOHN KLUENDER HAROLD CLINTON EUGENE BRITTELLI DAVID ROSS DIXON BRIAN RICHARD BULLOCK WILLIAM HARRISON |
| description | Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula(T)xA-B-D-E-Gwherein A and B are aryl or heteroaryl rings; each T is a substituent group; x is 0, 1, or 2; the group D represents the group E represents a three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents -M, in which M represents -CO2H, -CON(R11)2, or -CO2R12; and R13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids, and include pharmaceutically acceptable salts thereof. |
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The compounds of the invention have the generalized formula(T)xA-B-D-E-Gwherein A and B are aryl or heteroaryl rings; each T is a substituent group; x is 0, 1, or 2; the group D represents the group E represents a three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents -M, in which M represents -CO2H, -CON(R11)2, or -CO2R12; and R13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids, and include pharmaceutically acceptable salts thereof.</description><edition>7</edition><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001226&DB=EPODOC&CC=US&NR=6166082A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20001226&DB=EPODOC&CC=US&NR=6166082A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BENZ; GUENTER HANS HEINZ HERBERT</creatorcontrib><creatorcontrib>SCHNEIDER; STEPHAN</creatorcontrib><creatorcontrib>COMBS; KERRY JEANNE</creatorcontrib><creatorcontrib>WOOD; JILL ELIZABETH</creatorcontrib><creatorcontrib>WILHELM; SCOTT M</creatorcontrib><creatorcontrib>VANZANDT; MICHAEL CHRISTOPHER</creatorcontrib><creatorcontrib>WOLANIN; DONALD JOHN</creatorcontrib><creatorcontrib>KLUENDER; HAROLD CLINTON EUGENE</creatorcontrib><creatorcontrib>BRITTELLI; DAVID ROSS</creatorcontrib><creatorcontrib>DIXON; BRIAN RICHARD</creatorcontrib><creatorcontrib>BULLOCK; WILLIAM HARRISON</creatorcontrib><title>Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors</title><description>Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. 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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
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