Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula(T)xA-B-D-E-Gwherein A and B are aryl or heteroaryl rings; each T is a substitu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: BENZ, GUENTER HANS HEINZ HERBERT, SCHNEIDER, STEPHAN, COMBS, KERRY JEANNE, WOOD, JILL ELIZABETH, WILHELM, SCOTT M, VANZANDT, MICHAEL CHRISTOPHER, WOLANIN, DONALD JOHN, KLUENDER, HAROLD CLINTON EUGENE, BRITTELLI, DAVID ROSS, DIXON, BRIAN RICHARD, BULLOCK, WILLIAM HARRISON
Format: Patent
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula(T)xA-B-D-E-Gwherein A and B are aryl or heteroaryl rings; each T is a substituent group; x is 0, 1, or 2; the group D represents the group E represents a three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents -M, in which M represents -CO2H, -CON(R11)2, or -CO2R12; and R13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids, and include pharmaceutically acceptable salts thereof.