Process for synthesizing carbapenem intermediates

Process for synthesizing carbapenem intermediates

A process of synthesizing a compound of formula I is described: wherein P and P' independently represent H or a protecting group, R1 represents H or C1-4 alkyl, and Hal represents a halogen characterized by reacting a compound of formula 2: with R2OH, wherein R2 is C1-4 alkyl, C6-10 aryl or C5-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YASUDA, NOBUYOSHI, CHUNG, JOHN Y, LEAZER, JR., JOHNNIE L
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process of synthesizing a compound of formula I is described: wherein P and P' independently represent H or a protecting group, R1 represents H or C1-4 alkyl, and Hal represents a halogen characterized by reacting a compound of formula 2: with R2OH, wherein R2 is C1-4 alkyl, C6-10 aryl or C5-10 heteroaryl in the presence of an acid catalyst or carbodiimide reagent to produce a compound of formula 3: and reacting a compound of formula 3 in the presence of a base and a haloalkylating agent to produce a compound of formula 1.