Aromatic heterocyclic derivatives as enzyme inhibitors

Aromatic heterocyclic derivatives as enzyme inhibitors

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ABELMAN, MATTHEW M, TAMURA, SUSAN YOSHIKO, GE, YU, LIM-WILBY, MARGUERITA S. L, CARPENTER, STEPHEN H, BRUNCK, TERENCE K, RIPKA, WILLIAM CHARLES, NUTT, RUTH F, SEMPLE, JOSEPH EDWARD, ARDECKY, ROBERT JOHN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.