Transdominant negative proto-oncogene

The present invention provides a transrepressing protein of the Fos proto-oncogene family. The protein, FosB2, is characterized by having a leucine zipper domain and forming a heterodimer with a Jun related protein. This heterodimer is capable of binding to an AP-1 site and suppressing transcription...

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Bibliographische Detailangaben
Hauptverfasser:	VERMA, INDER M, YEN, JONG-YOUNG J, WISDOM, RONALD M
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a transrepressing protein of the Fos proto-oncogene family. The protein, FosB2, is characterized by having a leucine zipper domain and forming a heterodimer with a Jun related protein. This heterodimer is capable of binding to an AP-1 site and suppressing transcriptional transactivation of a promoter containing the AP-1 site.