Agent for suppressing tumor growth

PCT No. PCT/RU96/00060 Sec. 371 Date May 27, 1997 Sec. 102(e) Date May 27, 1997 PCT Filed Mar. 18, 1996 PCT Pub. No. WO97/03666 PCT Pub. Date Feb. 6, 1997The invention relates to the field of biology and medicine, in particular to suppression of the growth of malignant tumors. The object of the pres...

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Hauptverfasser:	VOROZHTSOV, GEORGY NIKOLAEVICH, ZHUKOVA, OLGA STEPANOVNA, LUKIYANETS, EVGENY ANTONOVICH, VOLPIN MARK EFIMOVICH, GALINA NIKOLAEVNA NOVODAROVA, GERASIMOVA, GALINA KONSTANTINOVNA, KALIA, OLEG LEONIDOVICH, CHISSOV, VALERY IVANOVICH, KRAINOVA, NADEZHDA JURIEVNA, KAZACHKINA, NATALYA IVANOVNA, LUZHKOV, JURY MIKHAILOVICH, YAKUBOVSKAYA, RAISA IVANOVNA, LEVITIN, ILYA YAKOVLEVICH, TRESCHALINA, ELENA MIKHAILOVNA, SYRKIN, ANATOLY BORISOVICH
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PCT No. PCT/RU96/00060 Sec. 371 Date May 27, 1997 Sec. 102(e) Date May 27, 1997 PCT Filed Mar. 18, 1996 PCT Pub. No. WO97/03666 PCT Pub. Date Feb. 6, 1997The invention relates to the field of biology and medicine, in particular to suppression of the growth of malignant tumors. The object of the present invention is to find more effective and less toxic drugs for suppression of tumor growth. The essence of the proposed invention is that in order to suppress tumor growth, a drug consisting of a biogenic reductant and a complex of cobalt or iron with substituted phthalocyanines (I) or naphthalocyanines (II) is used. where R=COONa, SO3Na, CH2C5H5N(+)Cl-, CH2(NH2)2S(+)CCl-. Use of the proposed drug makes it possible to suppress effectively the growth of a wide range of malignant tumors, in particular to achieve the suppression of proliferation of cancer cells (in vitro), inhibition of the growth of tumors in mice (in vivo) and a substantial increase in their life-span, including that obtained in comparison with use of the prototype.