Chemokine NC28 (monocyte chemotactic protein-3, MCP-3) polypeptides and their recombinant production

PCT No. PCT/FR91/00949 Sec. 371 Date Sep. 29, 1992 Sec. 102(e) Date Sep. 29, 1992 PCT Filed Nov. 29, 1990 PCT Pub. No. WO92/09629 PCT Pub. Date Jun. 11, 1992A new chemotactic cytokine, NC28 or Monocyte Chemotactic Protein-3 (MCP-3), is provided. Fragments of the cytokine comprising its 13 C-terminal...

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Hauptverfasser:	CAPUT, DANIEL, FERRARA, PASCUAL, MILOUX, BRIGITTE, VITA, NATALIO, MINTY, ADRIAN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	PCT No. PCT/FR91/00949 Sec. 371 Date Sep. 29, 1992 Sec. 102(e) Date Sep. 29, 1992 PCT Filed Nov. 29, 1990 PCT Pub. No. WO92/09629 PCT Pub. Date Jun. 11, 1992A new chemotactic cytokine, NC28 or Monocyte Chemotactic Protein-3 (MCP-3), is provided. Fragments of the cytokine comprising its 13 C-terminal amino acids also exhibit chemotactic activity. The polypeptides may be used as anticancer agents or immunomodulators. DNA encoding the NC28/MCP-3 polypeptides, as well as corresponding vectors and recombinant expression systems, are also provided.