Selective process for the deacylation of acylated compounds

Selective process for the deacylation of acylated compounds

PCT No. PCT/EP96/03495 Sec. 371 Date Apr. 23, 1997 Sec. 102(e) Date Apr. 23, 1997 PCT Filed Aug. 5, 1996 PCT Pub. No. WO97/06204 PCT Pub. Date Feb. 20, 1997The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermenta...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DE PATER, ROBERTUS M, SIBEYN, MIEKE
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:PCT No. PCT/EP96/03495 Sec. 371 Date Apr. 23, 1997 Sec. 102(e) Date Apr. 23, 1997 PCT Filed Aug. 5, 1996 PCT Pub. No. WO97/06204 PCT Pub. Date Feb. 20, 1997The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentation broth.