Combinatorial amide alcohol libraries

Combinatorial chemical libraries of the Formula [S]-C(O)-L'-Z containing dihyroxy amides and hydroxyphosphonate amides are disclosed, in which [S] represents a solid support and -L'-Z is a linker/ligand residue. In these libraries, Z is and Y is -P(O)(OR6)(OR7), -CH(OH)-COR8, -CH2CH=CH2-CH...

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Bibliographische Detailangaben
Hauptverfasser:	CAVALLARO, CULLEN LEE, DOLLE, III, ROLAND ELLWOOD, SHIMSHOCK, YVONNE CLASS, HERPIN, TIMOTHEE FELIX
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY COMBINATORIAL CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	Combinatorial chemical libraries of the Formula [S]-C(O)-L'-Z containing dihyroxy amides and hydroxyphosphonate amides are disclosed, in which [S] represents a solid support and -L'-Z is a linker/ligand residue. In these libraries, Z is and Y is -P(O)(OR6)(OR7), -CH(OH)-COR8, -CH2CH=CH2-CH2CH(OH)CH2OH, -CH2CHO, -CH2CH2OH, -CH2CH2OC(O)NHR26, -CH2CH2NR27R28, or The combinatorial libraries are optionally encoded with tags. The use of these libraries in assays to discover biologically active compounds is also disclosed.