Hydrazine derivative compounds as intermediates for preparing substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors
This invention relates to intermediate compounds which are useful for making substituted 1-phenyl-3-pyrazolecarboxamides. The compounds of the invention have the formula: in which: R'2 and R'3 each independently represent a hydrogen, a (C1-C6)alkyl, a (C3-C8)cycloalkyl, a (C3-C8)cycloalkyl...
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| creator | GULLY DANIELLE LABEEUW BERNARD MOLIMARD JEANARLES BOIGEGRAIN ROBERT JEANJEAN FRANCIS |
| description | This invention relates to intermediate compounds which are useful for making substituted 1-phenyl-3-pyrazolecarboxamides. The compounds of the invention have the formula: in which: R'2 and R'3 each independently represent a hydrogen, a (C1-C6)alkyl, a (C3-C8)cycloalkyl, a (C3-C8)cycloalkylmethyl; or R'2 and R'3 together constitute a trimethylene, tetramethylene or pentamethylene group; Ry is at position 4 or at position 5 and represents a group chosen from: cyano, carboxyl, (C1-C4)alkoxycarbonyl, benzyloxycarbonyl, sulpho, (C1-C4)alkylsulphonylamino, (C1-C4)alkylphenylsulphonylamino, carbamoyl, (C1-C4)alkylcarboxamido; on condition that R'2 and R'3 do not simultaneously represent hydrogen and on condition that R'2 is other than methyl when Ry is a sulpho group. The salts of the above compounds are also part of the invention. |
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The compounds of the invention have the formula: in which: R'2 and R'3 each independently represent a hydrogen, a (C1-C6)alkyl, a (C3-C8)cycloalkyl, a (C3-C8)cycloalkylmethyl; or R'2 and R'3 together constitute a trimethylene, tetramethylene or pentamethylene group; Ry is at position 4 or at position 5 and represents a group chosen from: cyano, carboxyl, (C1-C4)alkoxycarbonyl, benzyloxycarbonyl, sulpho, (C1-C4)alkylsulphonylamino, (C1-C4)alkylphenylsulphonylamino, carbamoyl, (C1-C4)alkylcarboxamido; on condition that R'2 and R'3 do not simultaneously represent hydrogen and on condition that R'2 is other than methyl when Ry is a sulpho group. The salts of the above compounds are also part of the invention.</description><edition>6</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990810&DB=EPODOC&CC=US&NR=5936123A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990810&DB=EPODOC&CC=US&NR=5936123A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GULLY; DANIELLE</creatorcontrib><creatorcontrib>LABEEUW; BERNARD</creatorcontrib><creatorcontrib>MOLIMARD; JEANARLES</creatorcontrib><creatorcontrib>BOIGEGRAIN; ROBERT</creatorcontrib><creatorcontrib>JEANJEAN; FRANCIS</creatorcontrib><title>Hydrazine derivative compounds as intermediates for preparing substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors</title><description>This invention relates to intermediate compounds which are useful for making substituted 1-phenyl-3-pyrazolecarboxamides. The compounds of the invention have the formula: in which: R'2 and R'3 each independently represent a hydrogen, a (C1-C6)alkyl, a (C3-C8)cycloalkyl, a (C3-C8)cycloalkylmethyl; or R'2 and R'3 together constitute a trimethylene, tetramethylene or pentamethylene group; Ry is at position 4 or at position 5 and represents a group chosen from: cyano, carboxyl, (C1-C4)alkoxycarbonyl, benzyloxycarbonyl, sulpho, (C1-C4)alkylsulphonylamino, (C1-C4)alkylphenylsulphonylamino, carbamoyl, (C1-C4)alkylcarboxamido; on condition that R'2 and R'3 do not simultaneously represent hydrogen and on condition that R'2 is other than methyl when Ry is a sulpho group. The salts of the above compounds are also part of the invention.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjDFOA1EMBbdJgQhnwBfYIqxAokQIlB6oI-f_F7C0a3_Z3ojlBrl1IkRPNc3MXHWn7VKdf0RBFS5HTjmCik3NZq1BHCSa8AlVOBF0MKfmaOyinxTzPlJyTlTa9O0Luoz90Lfl8rQRhX1v3zxJvZRcft-mpJjdEhqi5ChoaR7rbnXgMXDzx-vu9vXl_Xnbo9kO0bhAkbuPt_vH4WFzNzwN_xtnHptN6w</recordid><startdate>19990810</startdate><enddate>19990810</enddate><creator>GULLY; DANIELLE</creator><creator>LABEEUW; BERNARD</creator><creator>MOLIMARD; JEANARLES</creator><creator>BOIGEGRAIN; ROBERT</creator><creator>JEANJEAN; FRANCIS</creator><scope>EVB</scope></search><sort><creationdate>19990810</creationdate><title>Hydrazine derivative compounds as intermediates for preparing substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors</title><author>GULLY; DANIELLE ; LABEEUW; BERNARD ; MOLIMARD; JEANARLES ; BOIGEGRAIN; ROBERT ; JEANJEAN; FRANCIS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US5936123A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1999</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GULLY; DANIELLE</creatorcontrib><creatorcontrib>LABEEUW; BERNARD</creatorcontrib><creatorcontrib>MOLIMARD; JEANARLES</creatorcontrib><creatorcontrib>BOIGEGRAIN; ROBERT</creatorcontrib><creatorcontrib>JEANJEAN; FRANCIS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GULLY; DANIELLE</au><au>LABEEUW; BERNARD</au><au>MOLIMARD; JEANARLES</au><au>BOIGEGRAIN; ROBERT</au><au>JEANJEAN; FRANCIS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Hydrazine derivative compounds as intermediates for preparing substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors</title><date>1999-08-10</date><risdate>1999</risdate><abstract>This invention relates to intermediate compounds which are useful for making substituted 1-phenyl-3-pyrazolecarboxamides. The compounds of the invention have the formula: in which: R'2 and R'3 each independently represent a hydrogen, a (C1-C6)alkyl, a (C3-C8)cycloalkyl, a (C3-C8)cycloalkylmethyl; or R'2 and R'3 together constitute a trimethylene, tetramethylene or pentamethylene group; Ry is at position 4 or at position 5 and represents a group chosen from: cyano, carboxyl, (C1-C4)alkoxycarbonyl, benzyloxycarbonyl, sulpho, (C1-C4)alkylsulphonylamino, (C1-C4)alkylphenylsulphonylamino, carbamoyl, (C1-C4)alkylcarboxamido; on condition that R'2 and R'3 do not simultaneously represent hydrogen and on condition that R'2 is other than methyl when Ry is a sulpho group. The salts of the above compounds are also part of the invention.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Hydrazine derivative compounds as intermediates for preparing substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors |
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