Piperidine derivatives as substance P antagonists

Piperidine derivatives as substance P antagonists

PCT No. PCT/JP96/00796 Sec. 371 Date Sep. 26, 1997 Sec. 102(e) Date Sep. 26, 1997 PCT Filed Mar. 27, 1996 PCT Pub. No. WO96/30367 PCT Pub. Date Mar. 10, 1996Piperidine derivatives represented by general formula (I) or pharmaceutically acceptable acid addition salts thereof: wherein n represents an i...

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Hauptverfasser: OKAYAMA, AKIRA, SAKAMOTO, OSAMI, TANOUE, YOSHIHIRO, BEPPU, KOICHI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PCT No. PCT/JP96/00796 Sec. 371 Date Sep. 26, 1997 Sec. 102(e) Date Sep. 26, 1997 PCT Filed Mar. 27, 1996 PCT Pub. No. WO96/30367 PCT Pub. Date Mar. 10, 1996Piperidine derivatives represented by general formula (I) or pharmaceutically acceptable acid addition salts thereof: wherein n represents an integer of 0 or 1; X represents CH2, O or CH-CH3; R represents hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, substituted aminosulfonyl or nitro; R1 and R2 may be the same or different and each represents hydrogen or lower alkyl, are disclosed. The piperidine derivatives have an antagonism on Substance P and is useful as a preventive or remedy for asthma, vomiting, etc.