Medical device with biomolecule-coated surface graft matrix

A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the out...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CAHALAN, PATRICK T, HENDRIKS, MARC, LINDA L, VERHOEVEN, MICHEL, FOUACHE, BENEDICTE
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.