Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula wherein each T is a substituted group; x is 0, 1, or 2; the group D represents...

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Bibliographische Detailangaben
Hauptverfasser:	WILHELM, SCOTT MCCLELLAND, COMBS, KERRY JEANNE, VANZANDT, MICHAEL CHRISTOPHER, WOLANIN, DONALD JOHN, KLUENDER, HAROLD CLINTON EUGENE, BRITTELLI, DAVID ROSS, DIXON, BRIAN RICHARD, BULLOCK, WILLIAM HARRISON
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula wherein each T is a substituted group; x is 0, 1, or 2; the group D represents the group R6 represents a variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, in which M represents -CO2H, -CON(R11)2, or -CO2R12; and R13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.