Sialyl Lex analogues as inhibitors of cellular adhesion

The present invention relates to analogues of sialyl Lex that inhibit cellular adhesion between a selectin and cells that express sialyl Lex on their surfaces, as well as methods and compositions using the same, intermediates and methods for the preparation of the cellular adhesion inhibitor compoun...

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Bibliographische Detailangaben
Hauptverfasser:	DEFREES, SHAWN A
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE METALLURGY NANOTECHNOLOGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES SUGARS TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention relates to analogues of sialyl Lex that inhibit cellular adhesion between a selectin and cells that express sialyl Lex on their surfaces, as well as methods and compositions using the same, intermediates and methods for the preparation of the cellular adhesion inhibitor compounds and their intermediates. A contemplated intermediate or inhibitor compound has a structure that corresponds to that of Formula A, A