Cyclic peptides containing Arg-Gly-Asp, and derivatives thereof, as adhesion inhibitors

Cyclic peptides containing Arg-Gly-Asp, and derivatives thereof, as adhesion inhibitors

The invention relates to novel cyclopeptides of the formula Icyclo-(Arg-B-Asp-D-E)Iin which B, D, and E have the meanings defined herein, and their salts. These compounds act as integrin inhibitors and can be used, in particular, for the prophylaxis and treatment of disorders of the circulation and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KESSLER, HORST, WERMUTH, JOCHEN, HOLZEMANN, GUENTER, RIPPMANN, FRIEDRICH, DIEFENBACH, BEATE, HAUBNER, ROLAND, FELDING-HABERMANN, BRUNHILDE, JONCZYK, ALFRED
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to novel cyclopeptides of the formula Icyclo-(Arg-B-Asp-D-E)Iin which B, D, and E have the meanings defined herein, and their salts. These compounds act as integrin inhibitors and can be used, in particular, for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.