Phospholipase C-inhibiting peptides

PCT No. PCT/JP94/01486 Sec. 371 Date May 5, 1995 Sec. 102(e) Date May 5, 1995 PCT Filed Sep. 8, 1994 PCT Pub. No. WO95/07293 PCT Pub. Date Mar. 16, 1995The present invention relates to phopholipase C-inhibiting peptides which are represented by formula (I): (I) wherein J1 and J2 are each hydrogen or...

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Hauptverfasser: YAMASAKI, MOTOO, HONMA, YOSHIMI, ISHIKAWA, GENKICHI
Format: Patent
Sprache:eng
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Zusammenfassung:PCT No. PCT/JP94/01486 Sec. 371 Date May 5, 1995 Sec. 102(e) Date May 5, 1995 PCT Filed Sep. 8, 1994 PCT Pub. No. WO95/07293 PCT Pub. Date Mar. 16, 1995The present invention relates to phopholipase C-inhibiting peptides which are represented by formula (I): (I) wherein J1 and J2 are each hydrogen or combined together to form a single bond; W is hydrogen, a substituted or unsubstituted alkanoyl, a substituted or unsubstituted aroyl or coumaryl; X is a single bond, -Leu- or -Ser-Leu-Val-Glu-Leu-Val-Ser-Tyr-Tyr-Glu-Lys-His-Ala-Leu- (at least one of the N-terminal 14 amino acid residues may be deleted); Y is a single bond or -Pro-Val-; and Z is hydroxy or amino.