Lipid complexed topoisomerase I inhibitors

The present invention is described as a lipid-complexed topoisomerase I inhibitor (TII), for example camptothecin (CPT) preparation that allows for intravenous administration in vivo in clinically relevant lipid:drug ratios. The lipid formulation has in vitro antitumor activity similar to that of th...

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Bibliographische Detailangaben
Hauptverfasser:	SUGARMAN, STEVEN M, POIROT, KENNETH R, PEREZ-SOLER, ROMAN
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention is described as a lipid-complexed topoisomerase I inhibitor (TII), for example camptothecin (CPT) preparation that allows for intravenous administration in vivo in clinically relevant lipid:drug ratios. The lipid formulation has in vitro antitumor activity similar to that of the base compound and displays similar cytotoxicity against both MDR-1 negative and positive tumor cells.