16-methyl-11,16-dihydroxy-9-oxoprost-2,13-dien-1-oic acid and derivatives

16-methyl-11,16-dihydroxy-9-oxoprost-2,13-dien-1-oic acid and derivatives

Analogs of the prostaglandin PGE1 are disclosed. These compounds exhibit uterotonic properties, enhancing the response to PGF2 alpha in isolated rat uteri. The compounds also exhibit other pharmacological properties, as inhibitors of gastric acid secretion, hypotensives, and bronchodilators. Process...

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Bibliographische Detailangaben
Hauptverfasser: GIARCOVICH, SILVIA SUSANA, MAMMARELLA, CARLOS ALBERTO GENARO, BUSCHI, CARLOS ALBERTO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Analogs of the prostaglandin PGE1 are disclosed. These compounds exhibit uterotonic properties, enhancing the response to PGF2 alpha in isolated rat uteri. The compounds also exhibit other pharmacological properties, as inhibitors of gastric acid secretion, hypotensives, and bronchodilators. Processes for making the analogs, useful intermediates, and pharmaceutical preparations are also presented.