Production of recombinant factor Xa inhibitor of leech Hirudo medicinalis

The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr26-gly110 where tyr26-gly110 is identical to the sequence shown in FIG. 10, and wherein X is methionine or absent and wherein asn72 may be substituted by pro. The invention further provides a method of produ...

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Bibliographische Detailangaben
Hauptverfasser:	PANET, AMOS, ZEELON, ELISHA P, RIGBI, MEIR, WERBER, MOSHE M, GOLDLUST, ARIE, FISCHER, LEVANON, AVIGDOR, GUY, RACHEL
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr26-gly110 where tyr26-gly110 is identical to the sequence shown in FIG. 10, and wherein X is methionine or absent and wherein asn72 may be substituted by pro. The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.