Acylphenylglycine derivative and preventive and remedy for diseases caused by increased collagenase activity containing said compound as active ingredient

Acylphenylglycine derivative and preventive and remedy for diseases caused by increased collagenase activity containing said compound as active ingredient

PCT No. PCT/JP94/01284 Sec. 371 Date Feb. 8, 1996 Sec. 102(e) Date Feb. 8, 1996 PCT Filed Aug. 3, 1994 PCT Pub. No. WO95/04715 PCT Pub. Date Feb. 16, 1995An acylphenylglycine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a preventive and remedy for...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YAMAMOTO, MINORU, OBATA, YUJI, SAKAMOTO, FUMIO, IKEDA, SHOJI, MATSUO, KONOMI, TSUKIDA, TAKAHIRO, HIRAYAMA, RYOICHI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:PCT No. PCT/JP94/01284 Sec. 371 Date Feb. 8, 1996 Sec. 102(e) Date Feb. 8, 1996 PCT Filed Aug. 3, 1994 PCT Pub. No. WO95/04715 PCT Pub. Date Feb. 16, 1995An acylphenylglycine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a preventive and remedy for diseases caused by an increased collagenase activity containing the same as the active ingredient, wherein R1 represents hydrogen atom, methyl, methylaminomethyl or morpholinomethyl; R2 represents hydrogen atom, hydroxy, fluorine atom, or C1-C4 linear or branched alkyl; and R3 represents C1-C4 linear or branched alkyl. The compound (I) and the salt maintains a potent collagenase inhibitor activity in the blood for long after being administered, and are useful as a remedy for various diseases believed to be caused by an increased collagenase activity. (I)