Labeled chemotactic peptides to image focal sites of infection or inflammation

The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeuticall...

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Hauptverfasser: FUCCELLO, ANTHONY J, RUBIN, ROBERT H, KROON, DANIEL J, HERNANDEZ, PEDRO E, HIGGINS, III, JOHN D, LARSEN, SCOTT K, FISCHMAN, ALAN J, DERIAN, CLAUDIA K, BRIDGER, GARY J, STRAUSS, H. WILLIAM, SOLOMON, HOWARD F
Format: Patent
Sprache:eng
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Zusammenfassung:The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structureX-Y-Leu-Phe-[Z]n-Wwherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.