Inhibitors of squalene synthetase and protein farnesyltransferase
The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates usef...
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| creator | ROSENBERG SAUL H BAKER WILLIAM R FUNG ANTHONY K. L DONNER B. GREGORY O'CONNOR STEPHEN J SHEN WANG GARVEY DAVID S STOUT DAVID M ROCKWAY TODD W SULLIVAN GERARD M PRASAD RAJNANDAN N FAKHOURY STEPHEN A |
| description | The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.
The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds. |
| format | Patent |
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The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.</description><edition>6</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980721&DB=EPODOC&CC=US&NR=5783593A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980721&DB=EPODOC&CC=US&NR=5783593A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ROSENBERG; SAUL H</creatorcontrib><creatorcontrib>BAKER; WILLIAM R</creatorcontrib><creatorcontrib>FUNG; ANTHONY K. L</creatorcontrib><creatorcontrib>DONNER; B. GREGORY</creatorcontrib><creatorcontrib>O'CONNOR; STEPHEN J</creatorcontrib><creatorcontrib>SHEN; WANG</creatorcontrib><creatorcontrib>GARVEY; DAVID S</creatorcontrib><creatorcontrib>STOUT; DAVID M</creatorcontrib><creatorcontrib>ROCKWAY; TODD W</creatorcontrib><creatorcontrib>SULLIVAN; GERARD M</creatorcontrib><creatorcontrib>PRASAD; RAJNANDAN N</creatorcontrib><creatorcontrib>FAKHOURY; STEPHEN A</creatorcontrib><title>Inhibitors of squalene synthetase and protein farnesyltransferase</title><description>The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.
The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD0zMvITMosyS8qVshPUyguLE3MSc1LVSiuzCvJSC1JLE5VSMxLUSgoyi9JzcxTSEssykstrswpKUrMK05LLQLK8zCwpiXmFKfyQmluBnk31xBnD93Ugvz41OKCxGSgeSXxocGm5hbGppbGjsaEVQAAu0oyLg</recordid><startdate>19980721</startdate><enddate>19980721</enddate><creator>ROSENBERG; SAUL H</creator><creator>BAKER; WILLIAM R</creator><creator>FUNG; ANTHONY K. L</creator><creator>DONNER; B. GREGORY</creator><creator>O'CONNOR; STEPHEN J</creator><creator>SHEN; WANG</creator><creator>GARVEY; DAVID S</creator><creator>STOUT; DAVID M</creator><creator>ROCKWAY; TODD W</creator><creator>SULLIVAN; GERARD M</creator><creator>PRASAD; RAJNANDAN N</creator><creator>FAKHOURY; STEPHEN A</creator><scope>EVB</scope></search><sort><creationdate>19980721</creationdate><title>Inhibitors of squalene synthetase and protein farnesyltransferase</title><author>ROSENBERG; SAUL H ; BAKER; WILLIAM R ; FUNG; ANTHONY K. L ; DONNER; B. GREGORY ; O'CONNOR; STEPHEN J ; SHEN; WANG ; GARVEY; DAVID S ; STOUT; DAVID M ; ROCKWAY; TODD W ; SULLIVAN; GERARD M ; PRASAD; RAJNANDAN N ; FAKHOURY; STEPHEN A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US5783593A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1998</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>ROSENBERG; SAUL H</creatorcontrib><creatorcontrib>BAKER; WILLIAM R</creatorcontrib><creatorcontrib>FUNG; ANTHONY K. L</creatorcontrib><creatorcontrib>DONNER; B. GREGORY</creatorcontrib><creatorcontrib>O'CONNOR; STEPHEN J</creatorcontrib><creatorcontrib>SHEN; WANG</creatorcontrib><creatorcontrib>GARVEY; DAVID S</creatorcontrib><creatorcontrib>STOUT; DAVID M</creatorcontrib><creatorcontrib>ROCKWAY; TODD W</creatorcontrib><creatorcontrib>SULLIVAN; GERARD M</creatorcontrib><creatorcontrib>PRASAD; RAJNANDAN N</creatorcontrib><creatorcontrib>FAKHOURY; STEPHEN A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ROSENBERG; SAUL H</au><au>BAKER; WILLIAM R</au><au>FUNG; ANTHONY K. L</au><au>DONNER; B. GREGORY</au><au>O'CONNOR; STEPHEN J</au><au>SHEN; WANG</au><au>GARVEY; DAVID S</au><au>STOUT; DAVID M</au><au>ROCKWAY; TODD W</au><au>SULLIVAN; GERARD M</au><au>PRASAD; RAJNANDAN N</au><au>FAKHOURY; STEPHEN A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Inhibitors of squalene synthetase and protein farnesyltransferase</title><date>1998-07-21</date><risdate>1998</risdate><abstract>The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.
The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Inhibitors of squalene synthetase and protein farnesyltransferase |
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