Inhibitors of squalene synthetase and protein farnesyltransferase

The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates usef...

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Bibliographische Detailangaben
Hauptverfasser:	ROSENBERG, SAUL H, BAKER, WILLIAM R, FUNG, ANTHONY K. L, DONNER, B. GREGORY, O'CONNOR, STEPHEN J, SHEN, WANG, GARVEY, DAVID S, STOUT, DAVID M, ROCKWAY, TODD W, SULLIVAN, GERARD M, PRASAD, RAJNANDAN N, FAKHOURY, STEPHEN A
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds. The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.