Thymidylate analogs and the use thereof

Novel thymidylate analogs having the following formula are synthesized in the present invention, which are found active against human immunodeficiency virus type 1 (HIV-1): wherein R1 is hydrogen, cyano (-CN), halogen or azido (-N3); R2 is hydroxyl or an amino ester radical having a formula of -NHR4...

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Hauptverfasser: HAKIMELAHI, GHOLAM H, HWU, JIH RU, TSAY, SHWUN
Format: Patent
Sprache:eng
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Zusammenfassung:Novel thymidylate analogs having the following formula are synthesized in the present invention, which are found active against human immunodeficiency virus type 1 (HIV-1): wherein R1 is hydrogen, cyano (-CN), halogen or azido (-N3); R2 is hydroxyl or an amino ester radical having a formula of -NHR4COOR5, wherein R4 is a bivalent C1-C4 saturated hydrocarbon and R5 is C1-C4 alkyl; Me is methyl; and R3 is hydroxyl or thymidinyl having a formula as follows: