Quinolinecarboxylic acid derivatives

Quinolinecarboxylic acid derivatives

PCT No. PCT/JP95/00954 Sec. 371 Date Jan. 18, 1996 Sec. 102(e) Date Jan. 18, 1996 PCT Filed May 18, 1995 PCT Pub. No. WO95/31455 PCT Pub. Date Nov. 23, 1995Quinolinecarboxylic acid derivatives represented by the following formula: wherein C is hydroxymethyl, methoxy, ethoxy or morpholinyl, or pharma...

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Hauptverfasser: HATAYAMA, KATSUO, YOKOMORI, SADAKAZU, ASANUMA, HAJIME, OHUCHI, YUTAKA, SUZUKI, MASAJI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PCT No. PCT/JP95/00954 Sec. 371 Date Jan. 18, 1996 Sec. 102(e) Date Jan. 18, 1996 PCT Filed May 18, 1995 PCT Pub. No. WO95/31455 PCT Pub. Date Nov. 23, 1995Quinolinecarboxylic acid derivatives represented by the following formula: wherein C is hydroxymethyl, methoxy, ethoxy or morpholinyl, or pharmaceutically acceptable salts thereof exhibit a potent action for stimulating a serotonin 4 receptor. The compounds exhibit an action of enhancing the gastrointestinal motor function to improve the gastrointestinal conditions such as heartburn, anorexia, bowel pain, abdominal distension, etc., accompanied by chronic gastritis, diabetes mellitus or postoperative gastroparesis, and are thus effective for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction and constipation.\!