Synthesis and resolution of propionic acid derivatives

A process for the production of disubstituted propionic acid derivatives which are intermediates in the synthesis of alpha -arylpropionic acids such as naproxen, involves the reaction of a naphthalene derivative such as 2-methoxynaphthalene, with an alkylating agent such as an alkyl pyruvate in the...

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Hauptverfasser:	STEENKAMP, LUCIA HENDRINA, BRAITHWAITE, DANA HELEN, DAVIDSON, DEBORAH NICOLE, GARDINER, NEIL STOCKENSTROM, VAN EEDEN SKEIN, ETIENNE, NJAMELA, OWEN LUNGILE, PARKINSON, CHRISTOPHER JOHN, KHAILE, THEBEEAPELO JOHN, MARAIS, STEPHANUS FRANCOIS, JUNGMANN, CHRISTA MARIA
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A process for the production of disubstituted propionic acid derivatives which are intermediates in the synthesis of alpha -arylpropionic acids such as naproxen, involves the reaction of a naphthalene derivative such as 2-methoxynaphthalene, with an alkylating agent such as an alkyl pyruvate in the presence of a catalyst, and then dehydrating and hydrogenolising, or directly hydrogenolising, or derivatising and then hydrogenolising the product thereof, to produce the desired compound.