Ethylamido fluorenes and improved method of making same

Novel substituted fluorene compunds of Formula I are active as melatonergic agents: (I) wherein: X=H, halogen, OH or OZ; Z=C1-6 alkyl; -(CH2)m-CF3(m=0-2); CD3; or n=1 or 2; and R=C1-6 alkyl, C3-6 cycloalkyl, C2-4 alkenyl, halogen substituted C1-6 alkyl, or C1-6 alkoxy substituted C1-6 alkyl. Novel s...

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Bibliographische Detailangaben
Hauptverfasser:	EPPERSON, JAMES R, LEBOULLUEC, KAREN L, WATSON, BRETT T, TAKAKI, KATHERINE S, YEVICH, JOSEPH P, KARAGEORGE, GEORGE N
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Novel substituted fluorene compunds of Formula I are active as melatonergic agents: (I) wherein: X=H, halogen, OH or OZ; Z=C1-6 alkyl; -(CH2)m-CF3(m=0-2); CD3; or n=1 or 2; and R=C1-6 alkyl, C3-6 cycloalkyl, C2-4 alkenyl, halogen substituted C1-6 alkyl, or C1-6 alkoxy substituted C1-6 alkyl. Novel substituted fluorene compunds of Formula I are active as melatonergic agents: (I) wherein: X=H, halogen, OH or OZ; Z=C1-6 alkyl; -(CH2)m-CF3(m=0-2); CD3; or n=1 or 2; and R=C1-6 alkyl, C3-6 cycloalkyl, C2-4 alkenyl, halogen substituted C1-6 alkyl, or C1-6 alkoxy substituted C1-6 alkyl.