Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof

PCT No. PCT/HU92/00042 Sec. 371 Date Jul. 27, 1994 Sec. 102(e) Date Jul. 27, 1994 PCT Filed Oct. 30, 1992 PCT Pub. No. WO93/09107 PCT Pub. Date May 13, 1993A process is described for the preparation of 4-Methyl-5-(2-Chloroalkyl)-thiazole wherein the alkyl ranges from C2-C5, by providing the steps of...

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Hauptverfasser:	KISS, PAL, BAN, KAROLY, GONCZI, CSABA, NEMETH, ATTILA, SUTO, MIHALY, BUTTKAI, ILDIKO, MOLNAR NEE BAKO, ERZSEBET, KOEVARI, ARPAD, MORASZ, FERENC, GYORI, PETER, HEJA, GERGELY, GYURE, LEDNICZKY, LASZLO, PALOSI, ENDRE, SZALAY, GARACZY, SANDOR, MIHALOVICS, GYORGY, BONE, ISTVAN, SZVOBODA NEE KANZEL, IDA, SPERBER, SZABO NEE KARDOS, HUSZAR, KORBONITS, DEZSO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	PCT No. PCT/HU92/00042 Sec. 371 Date Jul. 27, 1994 Sec. 102(e) Date Jul. 27, 1994 PCT Filed Oct. 30, 1992 PCT Pub. No. WO93/09107 PCT Pub. Date May 13, 1993A process is described for the preparation of 4-Methyl-5-(2-Chloroalkyl)-thiazole wherein the alkyl ranges from C2-C5, by providing the steps of either a) converting the 3-thiocyanato-5-chloro-2-alkanone into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole by gaseous hydrochloric acid in an organic solvent and hydrogenating the compound in the presence of a metal catalyst in an organic solvent, or b) reacting 3-thiocyanato-5-choro-2-alkanone with aqueous mineral acid and treating the thiazole obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole in an organic solvent in presence of a metal catalyst.