Natural amino acid derivatives as metalloproteinase inhibitors
PCT No. PCT/GB93/01556 Sec. 371 Date Jan. 23, 1995 Sec. 102(e) Date Jan. 23, 1995 PCT Filed Jul. 23, 1993 PCT Pub. No. WO94/02446 PCT Pub. Date Feb. 3, 1994 (I) Compounds of Formula (I) wherein R2 represents a group R6-A- wherein A represents a divalent straight or branched, saturated or unsaturated...
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| creator | DICKENS JONATHAN PHILIP CRIMMIN MICHAEL JOHN BECKETT RAYMOND PAUL |
| description | PCT No. PCT/GB93/01556 Sec. 371 Date Jan. 23, 1995 Sec. 102(e) Date Jan. 23, 1995 PCT Filed Jul. 23, 1993 PCT Pub. No. WO94/02446 PCT Pub. Date Feb. 3, 1994 (I) Compounds of Formula (I) wherein R2 represents a group R6-A- wherein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 6 C atoms which may be interrupted by an O or S atom, and R6 represents hydrogen or an optionally substituted phenyl, cycloalkyl or cycloalkenyl group; R3 represents the characterizing side chain of a natural alpha amino acid other than proline, and in which any polar substituents are optionally protected; R4 represents hydrogen or methyl; R5 represents hydrogen, C1-C6 alkyl or a group D-(C1-C6 alkyl) wherein D represents hydroxy, (C1-C6)alkoxy, (C1-C6)alkylthio, acylamino, optionally substituted phenyl, or a heterocyclic group, NH2, or a mono- or di-(C1-C6 alkyl) amine or a heterocyclic group; or R3 and R5 taken together represent a divalent, saturated or unsaturated hydrocarbon chain of from 8-14 C atoms, which may be interrupted by an O, S or N heteroatom, or a salt, solvate or hydrate thereof. |
| format | Patent |
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No. WO94/02446 PCT Pub. Date Feb. 3, 1994 (I) Compounds of Formula (I) wherein R2 represents a group R6-A- wherein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 6 C atoms which may be interrupted by an O or S atom, and R6 represents hydrogen or an optionally substituted phenyl, cycloalkyl or cycloalkenyl group; R3 represents the characterizing side chain of a natural alpha amino acid other than proline, and in which any polar substituents are optionally protected; R4 represents hydrogen or methyl; R5 represents hydrogen, C1-C6 alkyl or a group D-(C1-C6 alkyl) wherein D represents hydroxy, (C1-C6)alkoxy, (C1-C6)alkylthio, acylamino, optionally substituted phenyl, or a heterocyclic group, NH2, or a mono- or di-(C1-C6 alkyl) amine or a heterocyclic group; or R3 and R5 taken together represent a divalent, saturated or unsaturated hydrocarbon chain of from 8-14 C atoms, which may be interrupted by an O, S or N heteroatom, or a salt, solvate or hydrate thereof.</description><edition>6</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1997</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970701&DB=EPODOC&CC=US&NR=5643964A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970701&DB=EPODOC&CC=US&NR=5643964A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DICKENS; JONATHAN PHILIP</creatorcontrib><creatorcontrib>CRIMMIN; MICHAEL JOHN</creatorcontrib><creatorcontrib>BECKETT; RAYMOND PAUL</creatorcontrib><title>Natural amino acid derivatives as metalloproteinase inhibitors</title><description>PCT No. PCT/GB93/01556 Sec. 371 Date Jan. 23, 1995 Sec. 102(e) Date Jan. 23, 1995 PCT Filed Jul. 23, 1993 PCT Pub. No. WO94/02446 PCT Pub. Date Feb. 3, 1994 (I) Compounds of Formula (I) wherein R2 represents a group R6-A- wherein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 6 C atoms which may be interrupted by an O or S atom, and R6 represents hydrogen or an optionally substituted phenyl, cycloalkyl or cycloalkenyl group; R3 represents the characterizing side chain of a natural alpha amino acid other than proline, and in which any polar substituents are optionally protected; R4 represents hydrogen or methyl; R5 represents hydrogen, C1-C6 alkyl or a group D-(C1-C6 alkyl) wherein D represents hydroxy, (C1-C6)alkoxy, (C1-C6)alkylthio, acylamino, optionally substituted phenyl, or a heterocyclic group, NH2, or a mono- or di-(C1-C6 alkyl) amine or a heterocyclic group; or R3 and R5 taken together represent a divalent, saturated or unsaturated hydrocarbon chain of from 8-14 C atoms, which may be interrupted by an O, S or N heteroatom, or a salt, solvate or hydrate thereof.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1997</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyjEKwkAQBdBtLEQ9g3OBVIkBG0HEYGWj1uGbjDiw2Vl2xpzfxt7qNW8ZDlf4pyASJklKGGSkkYvMcJnZCEYTO2LUXNRZEoxJ0lue4lpsHRYvROPNz1XYduf76VJx1p4tY-DE3j9uu7ap921zrP-PL-cOMLI</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>DICKENS; JONATHAN PHILIP</creator><creator>CRIMMIN; MICHAEL JOHN</creator><creator>BECKETT; RAYMOND PAUL</creator><scope>EVB</scope></search><sort><creationdate>19970701</creationdate><title>Natural amino acid derivatives as metalloproteinase inhibitors</title><author>DICKENS; JONATHAN PHILIP ; CRIMMIN; MICHAEL JOHN ; BECKETT; RAYMOND PAUL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US5643964A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1997</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DICKENS; JONATHAN PHILIP</creatorcontrib><creatorcontrib>CRIMMIN; MICHAEL JOHN</creatorcontrib><creatorcontrib>BECKETT; RAYMOND PAUL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DICKENS; JONATHAN PHILIP</au><au>CRIMMIN; MICHAEL JOHN</au><au>BECKETT; RAYMOND PAUL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Natural amino acid derivatives as metalloproteinase inhibitors</title><date>1997-07-01</date><risdate>1997</risdate><abstract>PCT No. PCT/GB93/01556 Sec. 371 Date Jan. 23, 1995 Sec. 102(e) Date Jan. 23, 1995 PCT Filed Jul. 23, 1993 PCT Pub. No. WO94/02446 PCT Pub. Date Feb. 3, 1994 (I) Compounds of Formula (I) wherein R2 represents a group R6-A- wherein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 6 C atoms which may be interrupted by an O or S atom, and R6 represents hydrogen or an optionally substituted phenyl, cycloalkyl or cycloalkenyl group; R3 represents the characterizing side chain of a natural alpha amino acid other than proline, and in which any polar substituents are optionally protected; R4 represents hydrogen or methyl; R5 represents hydrogen, C1-C6 alkyl or a group D-(C1-C6 alkyl) wherein D represents hydroxy, (C1-C6)alkoxy, (C1-C6)alkylthio, acylamino, optionally substituted phenyl, or a heterocyclic group, NH2, or a mono- or di-(C1-C6 alkyl) amine or a heterocyclic group; or R3 and R5 taken together represent a divalent, saturated or unsaturated hydrocarbon chain of from 8-14 C atoms, which may be interrupted by an O, S or N heteroatom, or a salt, solvate or hydrate thereof.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Natural amino acid derivatives as metalloproteinase inhibitors |
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