Natural amino acid derivatives as metalloproteinase inhibitors

PCT No. PCT/GB93/01556 Sec. 371 Date Jan. 23, 1995 Sec. 102(e) Date Jan. 23, 1995 PCT Filed Jul. 23, 1993 PCT Pub. No. WO94/02446 PCT Pub. Date Feb. 3, 1994 (I) Compounds of Formula (I) wherein R2 represents a group R6-A- wherein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 6 C atoms which may be interrupted by an O or S atom, and R6 represents hydrogen or an optionally substituted phenyl, cycloalkyl or cycloalkenyl group; R3 represents the characterizing side chain of a natural alpha amino acid other than proline, and in which any polar substituents are optionally protected; R4 represents hydrogen or methyl; R5 represents hydrogen, C1-C6 alkyl or a group D-(C1-C6 alkyl) wherein D represents hydroxy, (C1-C6)alkoxy, (C1-C6)alkylthio, acylamino, optionally substituted phenyl, or a heterocyclic group, NH2, or a mono- or di-(C1-C6 alkyl) amine or a heterocyclic group; or R3 and R5 taken together represent a divalent, saturated or unsaturated hydrocarbon chain of from 8-14 C atoms, which may be interrupted by an O, S or N heteroatom, or a salt, solvate or hydrate thereof.