Modified pseudomonas exotoxin PE40

Pseudomonas exotoxin 40 is modified by deleting or substituting one or more cysteine residues. Such a modified protein, when hybridized to TGF alpha , exhibits altered biological activities from unmodified TGF alpha PE40, including decreased cell killing activity and increased receptor-binding activ...

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Bibliographische Detailangaben
Hauptverfasser:	STIRDIVANT, STEVEN M, RIEMEN, MARK W
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Pseudomonas exotoxin 40 is modified by deleting or substituting one or more cysteine residues. Such a modified protein, when hybridized to TGF alpha , exhibits altered biological activities from unmodified TGF alpha PE40, including decreased cell killing activity and increased receptor-binding activity.