Process for preparing aprotinin and aprotinin analogs in yeast cells

Process for preparing aprotinin and aprotinin analogs in yeast cells

The present invention relates to methods for producing aprotinin and analogs thereof in yeast, synthetic genes encoding such products, expression vectors and transformed yeast cells. The invention further relates to aprotinin analogs, particularly analogs with increased specific inhibitory activity...

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Bibliographische Detailangaben
Hauptverfasser: BREGENGAARD, CLAUS, DINESS, VIGGO, N+526 RSKOV-LAURITSEN, LEIF, NORRIS, KJELD, CHRISTENSEN, NIELS D, BJ+526 RN, SOREN E, FANNY, PETERSEN, LARS C
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to methods for producing aprotinin and analogs thereof in yeast, synthetic genes encoding such products, expression vectors and transformed yeast cells. The invention further relates to aprotinin analogs, particularly analogs with increased specific inhibitory activity and/or reduced nephrotoxicity compared to native aprotinin, as well as compositions comprising such analogs.