Substituted 1,1,2-triphenylbutenes and their use in the treatment of cancer

PCT No. PCT/GB93/00889 Sec. 371 Date Jan. 17, 1995 Sec. 102(e) Date Jan. 17, 1995 PCT Filed Apr. 29, 1993 PCT Pub. No. WO93/22275 PCT Pub. Date Nov. 11, 1993Compounds of the general formula (2) (2) wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R1 and R2, which may be the same or different, represent C1-3 alkyl, especially methyl or ethyl, groups or Rl represents a hydrogen atom and R2 a C1-3 alkyl group or R1 and R2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group, especially a pyrrolidino group, in the form of their free bases or pharmaceutically acceptable acid addition salts are potent anti-oestrogenic compounds useful for treatment of oestrogen-dependent cancers, especially breast cancers. Compounds where the iodine atom is radioisotopic are useful in radiotherapy or gamma ray imaging of these cancers.