Protease-binding compounds and methods of use

Non-peptide, protease-binding compounds are described as useful in the detection, labelling, and inhibition of retroviral proteases. Aryl piperidinyl derivatives and other compounds related in structure have been found to be HIV-1 and HIV-2 protease-binding compounds.

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Bibliographische Detailangaben
Hauptverfasser:	CRAIK, CHARLES S, DE VOSS, JAMES, BABE, LILIA M, ALVAREZ, JUAN C, KUNTZ, IRWIN D, CALDERA, PATRICIA S, FURTH, PAUL S, SALTO, RAFAEL, DECAMP, DIANNE L, SUI, ZHIHUA, ORTIZ DE MONTELLANO, PAUL R
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	Non-peptide, protease-binding compounds are described as useful in the detection, labelling, and inhibition of retroviral proteases. Aryl piperidinyl derivatives and other compounds related in structure have been found to be HIV-1 and HIV-2 protease-binding compounds.