Process for the preparation of taurocholanic acids

A process is described for the preparation of taurocholanic acids of formula (I): (I) in which A completes the 5 beta -cyclopentaneperhydrophenanthrene structure of a cholanic acid and E is hydrogen or a methyl group, by reacting the corresponding cholanic acid with the chloride of an acid having a...

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Hauptverfasser: ROSSETTI, VITTORIO, AROSIO, ROBERTO
Format: Patent
Sprache:eng
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Zusammenfassung:A process is described for the preparation of taurocholanic acids of formula (I): (I) in which A completes the 5 beta -cyclopentaneperhydrophenanthrene structure of a cholanic acid and E is hydrogen or a methyl group, by reacting the corresponding cholanic acid with the chloride of an acid having a tertiary carbon in the alpha-position, and treating the resulting mixed anhydride with taurine. A process is described for the preparation of taurocholanic acids of formula (I): (I) in which A completes the 5 beta -cyclopentaneperhydrophenanthrene structure of a cholanic acid and E is hydrogen or a methyl group, by reacting the corresponding cholanic acid with the chloride of an acid having a tertiary carbon in the alpha-position, and treating the resulting mixed anhydride with taurine.