Humanized antibodies that recognize difucosyl Lewis blood group antigens Y-6 and B-7-2

Humanized monoclonal antibodies that recognize the difucosyl Lewis blood group antigens Y-6 and B-7-2 are disclosed. The antibodies have a humanized light chain variable region and a humanized heavy chain variable region with CDRs from antibody BR55-2. Fragments of the antibodies and pharmaceutical...

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Bibliographische Detailangaben
Hauptverfasser:	CO, MAN S, LOIBNER, HANS
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Humanized monoclonal antibodies that recognize the difucosyl Lewis blood group antigens Y-6 and B-7-2 are disclosed. The antibodies have a humanized light chain variable region and a humanized heavy chain variable region with CDRs from antibody BR55-2. Fragments of the antibodies and pharmaceutical compositions containing them are also disclosed.