5-nitrobenzo[de]isoquinoline-1,3-diones their preparation and their use

An antitumor 5-nitrobenzo[de]isoquinoline-1,3-dione of the formula I I where n is 1 or 2, R1 and R2 are identical or different and are each hydrogen, C1-C6-alkyl, C1-C6-hydroxyalkyl, pyrrolidinyl, morpholino, piperidinyl or piperacinyl and R3 and R4 are identical or different and are each hydrogen,...

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Hauptverfasser:	MOR+E,ACU A+EE N MOSET, MARINA, CASTELLANO BERLANGA, JOS+E,ACU E+EE M, SCHLICK, ERICH, BRA+E,OTL N+EE A, MIGUEL F, KEILHAUER, GERHARD
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	An antitumor 5-nitrobenzo[de]isoquinoline-1,3-dione of the formula I I where n is 1 or 2, R1 and R2 are identical or different and are each hydrogen, C1-C6-alkyl, C1-C6-hydroxyalkyl, pyrrolidinyl, morpholino, piperidinyl or piperacinyl and R3 and R4 are identical or different and are each hydrogen, C1-C6-alkyl, C1-C6-acyl, C2--C7-alkoxycarbonyl, ureyl, aminocarbonyl or C2-C7-alkylaminocarbonyl, and its salts with physiologically tolerated acids, are described. An antitumor 5-nitrobenzo[de]isoquinoline-1,3-dione of the formula I I where n is 1 or 2, R1 and R2 are identical or different and are each hydrogen, C1-C6-alkyl, C1-C6-hydroxyalkyl, pyrrolidinyl, morpholino, piperidinyl or piperacinyl and R3 and R4 are identical or different and are each hydrogen, C1-C6-alkyl, C1-C6-acyl, C2--C7-alkoxycarbonyl, ureyl, aminocarbonyl or C2-C7-alkylaminocarbonyl, and its salts with physiologically tolerated acids, are described.