Arylsulfonamido-substituted hydroxamic acids

The invention relates to the compounds of formula I (I) pharmaceutically acceptable prodrug derivatives and pharmaceutically acceptable salts thereof; methods for preparation thereof; pharmaceutical compositions comprising said compounds; and a method of inhibiting matrix-degrading metalloproteinase...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MACPHERSON, LAWRENCE J, PARKER, DAVID T
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to the compounds of formula I (I) pharmaceutically acceptable prodrug derivatives and pharmaceutically acceptable salts thereof; methods for preparation thereof; pharmaceutical compositions comprising said compounds; and a method of inhibiting matrix-degrading metalloproteinase and of treating matrix-degrading metalloproteinase dependent conditions in mammals using such compounds. The invention relates to the compounds of formula I (I) pharmaceutically acceptable prodrug derivatives and pharmaceutically acceptable salts thereof; methods for preparation thereof; pharmaceutical compositions comprising said compounds; and a method of inhibiting matrix-degrading metalloproteinase and of treating matrix-degrading metalloproteinase dependent conditions in mammals using such compounds.