Heterocycle-substituted benzenemethanamine derivatives

The present invention is concerned with antiretroviral (e.g. anti-HIV-1) compounds having the formula (I) wherein R1 and R2 each independently are halo or methyl; R3 is hydrogen, halo, nitro or trifluoromethyl; R4 is trifluoromethyl or methylcarbonyl; or a radical -C(=X)-NR5R6 wherein X is O or S, a...

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Bibliographische Detailangaben
Hauptverfasser:	VAN DAELE, GEORGES H. P, VERDONCK, MARC G. C, BOSMANS, JEAN-PAUL R. M. A, JANSSEN, MARCEL A. C, PAUL A. J
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is concerned with antiretroviral (e.g. anti-HIV-1) compounds having the formula (I) wherein R1 and R2 each independently are halo or methyl; R3 is hydrogen, halo, nitro or trifluoromethyl; R4 is trifluoromethyl or methylcarbonyl; or a radical -C(=X)-NR5R6 wherein X is O or S, and R5 and R6 each independently are hydrogen or C1-4alkyl; or a radical -Alk-R7, wherein Alk is C1-4alkanediyl; and R7 is hydrogen or hydroxy; Het is a heterocyclic radical of formula: GE> (d) (e) Pharmaceutical compositions containing said compounds of formula (I) and processes of preparing said compounds and compositions.