Oral pharmaceutical composition containing cyclosporin and process for preparing same

The invention relates to a pharmaceutical composition for oral administration containing cyclosporin A and/or cyclosporin G as active ingredient, which possess advantageous absorption characteristics, and to a process for preparing this composition. The composition according to the invention compris...

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Bibliographische Detailangaben
Hauptverfasser:	ISTVAN, KOVACS, SANDOR, JANCSO, ERNO, ORBAN, LAZLONE, TOMORI, ANTALNE, TIBOR, BALOGH, TAMASNE, KISS, MARIA, KUERTHY, ISTVANNE, JUSZTIN, ERZSEBET, TAKACS, LASZLO, JASZLITS, IMRE, MORAVCSIK
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a pharmaceutical composition for oral administration containing cyclosporin A and/or cyclosporin G as active ingredient, which possess advantageous absorption characteristics, and to a process for preparing this composition. The composition according to the invention comprises 1 part by mass of one or more cyclosporin(s) dissolved in 4 to 50 parts by volume of propylene glycol, 0 to 25 parts by volume of ethanol and 0.0 to 5 parts by mass of a polyoxyethylene/polyoxypropylene block polymer in homogenized state. Based on examinations carried out at 100 DEG C., the stability of solutions prepared according to the invention does not differ from that of the commercially available Sandimmun oral solution.