Serine protease variants having peptide ligase activity

PCT No. PCT/US91/05480 Sec. 371 Date Feb. 26, 1993 Sec. 102(e) Date Feb. 26, 1993 PCT Filed Aug. 6, 1991 PCT Pub. No. WO92/02615 PCT Pub. Date Feb. 20, 1992.The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form prote...

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Hauptverfasser:	ABRAHMSEN, LARS B, WELLS, JAMES A, BURNIER, JOHN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Zusammenfassung:	PCT No. PCT/US91/05480 Sec. 371 Date Feb. 26, 1993 Sec. 102(e) Date Feb. 26, 1993 PCT Filed Aug. 6, 1991 PCT Pub. No. WO92/02615 PCT Pub. Date Feb. 20, 1992.The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates which in combination with the serine protease variants and a second ligation substrate are capable of forming a ligation product. The invention also relates to methods for forming such ligation products and the products formed thereby.