3-deoxy-mannosamine derivatives

3-deoxy-mannosamine derivatives

The present invention relates to 3-deoxy-derivatives of D-mannosamine of formula (I) wherein R is -NH2 or a C2-5 alkanoyl-NH- or CF3CONH- group; each of R1 and R2 independently is C1-C4 alkyl, or R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy, and R2 is hydrogen or both of R1 and R2 are fluori...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GERONI, CRISTINA, BARGIOTTI, ALBERTO, ONETO, NUCCIA, MONGELLI, NICOLA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:The present invention relates to 3-deoxy-derivatives of D-mannosamine of formula (I) wherein R is -NH2 or a C2-5 alkanoyl-NH- or CF3CONH- group; each of R1 and R2 independently is C1-C4 alkyl, or R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy, and R2 is hydrogen or both of R1 and R2 are fluorine; and wherein, when R1 is methoxy and R2 is hydrogen then R is other than -NH2, or a pharmaceutically acceptable salt thereof, which are useful as angiogenesis inhibitors, in particular as development of metastasis inhibitors.